Depressed Long Term Depression (LTD)
There is no greater sorrow
Than to be mindful of the happy time
In misery.
- Dante Alighieri (1265-1321)
You Look Happy With that Nose Piercing, said the Optimist
Depressed Long Term Depression (LTD)
Inspired by Dante Alighieri (1265-1321)'s quote, "There is no greater sorrow, Than to be mindful of the happy time , In misery." The titled responsion referrs to the delayed parsing functionality, holding on, if you will of something that once was. In the form of a story I believe it begins with, "Once upon a time..."
In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.
As the opposing process to long-term potentiation (LTP), LTD is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. This is necessary because, if allowed to continue increasing in strength, synapses would ultimately reach a ceiling level of efficiency, which would inhibit the encoding of new information. Both LTD and LTP are forms of synaptic plasticity.
Should I come back later?
Inspired by Edgar Allan Poe (1809-1849)'s quote, "Deep into that darkness peering, long I stood there, wondering, fearing, doubting, dreaming dreams no mortal ever dared to dream before". The titled responsion is poking fun of a brillant mind in deep and maybe to serious a thought.
I come back to this piece, as many do, to reflect on what this means, to me and to humanity. To others, I can pretend that they too share a similar affection.
Spoken like a true pessimist, your writing tells another truth.
Inspired by George Steiner (1929-2020)'s quote, "I'm sorry, I'm absolutely convinced that there is at the moment no realistic prospect for very much hope in human affairs." The titled responsion is...
This graduated role reversal of humility is an act worth thinking about. Revolutions take place despite our preoccupation with initiation. As the world turns, living is perpetual, limited to our species in language only.
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Daniel Sanderson